@article {FujitaENEURO.0217-18.2018, author = {Kyota Fujita and Hidenori Homma and Kanoh Kondo and Masashi Ikuno and Hodaka Yamakado and Kazuhiko Tagawa and Shigeo Murayama and Ryosuke Takahashi and Hitoshi Okazawa}, title = {Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology}, volume = {5}, number = {4}, elocation-id = {ENEURO.0217-18.2018}, year = {2018}, doi = {10.1523/ENEURO.0217-18.2018}, publisher = {Society for Neuroscience}, abstract = {Phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) reflects neurite degeneration at the early stage of Alzheimer{\textquoteright}s disease (AD), before extracellular Aβ aggregates are histologically detectable. Here, we demonstrate that similar changes in MARCKS occur in Parkinson{\textquoteright}s disease (PD) and dementia with Lewy bodies (DLB) pathologies in both mouse models and human patients. The increase in the level of pSer46-MARCKS began before α-synuclein aggregate formation, at a time when human α-Syn-BAC-Tg/GBA-hetero-KO mice exhibited no symptoms, and was sustained during aging, consistent with the pattern in human postmortem brains. The results strongly imply a common mechanism of pre-aggregation neurite degeneration in AD and PD/DLB pathologies.}, URL = {https://www.eneuro.org/content/5/4/ENEURO.0217-18.2018}, eprint = {https://www.eneuro.org/content/5/4/ENEURO.0217-18.2018.full.pdf}, journal = {eNeuro} }