PT  - JOURNAL ARTICLE
AU  - Zachary Zeidler
AU  - Mikaela Brandt-Fontaine
AU  - Caara Leintz
AU  - Chris Krook-Magnuson
AU  - Tay Netoff
AU  - Esther Krook-Magnuson
TI  - Targeting the Mouse Ventral Hippocampus in the Intrahippocampal Kainic Acid Model of Temporal Lobe Epilepsy
AID  - 10.1523/ENEURO.0158-18.2018
DP  - 2018 Jul 01
TA  - eneuro
PG  - ENEURO.0158-18.2018
VI  - 5
IP  - 4
4099  - http://www.eneuro.org/content/5/4/ENEURO.0158-18.2018.short
4100  - http://www.eneuro.org/content/5/4/ENEURO.0158-18.2018.full
SO  - eNeuro2018 Jul 01; 5
AB  - Here we describe a novel mouse model of temporal lobe epilepsy (TLE) that moves the site of kainate injection from the rodent dorsal hippocampus (corresponding to the human posterior hippocampus) to the ventral hippocampus (corresponding to the human anterior hippocampus). We compare the phenotypes of this new model—with respect to seizures, cognitive impairment, affective deficits, and histopathology—to the standard dorsal intrahippocampal kainate model. Our results demonstrate that histopathological measures of granule cell dispersion and mossy fiber sprouting maximize near the site of kainate injection. Somewhat surprisingly, both the dorsal and ventral models exhibit similar spatial memory impairments in addition to similar electrographic and behavioral seizure burdens. In contrast, we find a more pronounced affective (anhedonic) phenotype specifically in the ventral model. These results demonstrate that the ventral intrahippocampal kainic acid model recapitulates critical pathologies of the dorsal model while providing a means to further study affective phenotypes such as depression in TLE.