TY - JOUR T1 - An Emerging Role for RNA in a Memory-Like Behavioral Effect in <em>Aplysia</em> JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0193-18.2018 VL - 5 IS - 3 SP - ENEURO.0193-18.2018 AU - Rosalind SE Carney Y1 - 2018/05/01 UR - http://www.eneuro.org/content/5/3/ENEURO.0193-18.2018.abstract N2 - Highlighted Research Paper: RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia, by Alexis Bédécarrats, Shanping Chen, Kaycey Pearce, Diancai Cai and David L. GlanzmanFor over a century, the predominant view in memory research has been that the engram, the physical substrate of memory, is stored at the synapse. Research from several laboratories has identified roles for protein synthesis and methylation during critical time periods of memory consolidation and storage (for review, see Day and Sweatt, 2010; Kandel et al., 2014; Marshall and Bredy, 2016; Poo et al., 2016). However, research in the sea snail, Aplysia, suggests that although protein synthesis and methylation remain universal to the consolidation of long-term memories in this species, the cellular location in which memory storage occurs may differ. David Glanzman (UCLA) and his laboratory have exploited the simplicity of the Aplysia nervous system for memory research because of several unique features of this model. Their research implicates the nucleus … ER -