RT Journal Article
SR Electronic
T1 Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer’s Disease
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0426-17.2018
DO 10.1523/ENEURO.0426-17.2018
VO 5
IS 2
A1 Rosalind Brown
A1 Alice D. Lam
A1 Alfredo Gonzalez-Sulser
A1 Andrew Ying
A1 Mary Jones
A1 Robert Chang-Chih Chou
A1 Makis Tzioras
A1 Crispin Y. Jordan
A1 Izabela Jedrasiak-Cape
A1 Anne-Laure Hemonnot
A1 Maurice Abou Jaoude
A1 Andrew J. Cole
A1 Sydney S. Cash
A1 Takashi Saito
A1 Takaomi Saido
A1 Richard R. Ribchester
A1 Kevan Hashemi
A1 Iris Oren
YR 2018
UL http://www.eneuro.org/content/5/2/ENEURO.0426-17.2018.abstract
AB Network hyperexcitability is a feature of Alzheimer’ disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. We studied network hyperexcitability in mice expressing amyloid precursor protein (APP) with mutations that cause familial AD, and compared a transgenic model that overexpresses human APP (hAPP) (J20), to a knock-in model expressing APP at physiological levels (APPNL/F). We recorded continuous long-term electrocorticogram (ECoG) activity from mice, and studied modulation by circadian cycle, behavioral, and brain state. We report that while J20s exhibit frequent interictal spikes (IISs), APPNL/F mice do not. In J20 mice, IISs were most prevalent during daylight hours and the circadian modulation was associated with sleep. Further analysis of brain state revealed that IIS in J20s are associated with features of rapid eye movement (REM) sleep. We found no evidence of cholinergic changes that may contribute to IIS-circadian coupling in J20s. In contrast to J20s, intracranial recordings capturing IIS in AD patients demonstrated frequent IIS in non-REM (NREM) sleep. The salient differences in sleep-stage coupling of IIS in APP overexpressing mice and AD patients suggests that different mechanisms may underlie network hyperexcitability in mice and humans. We posit that sleep-stage coupling of IIS should be an important consideration in identifying mouse AD models that most closely recapitulate network hyperexcitability in human AD.