RT Journal Article
SR Electronic
T1 Electrical Stimulation Modulates High γ Activity and Human Memory Performance
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0369-17.2018
DO 10.1523/ENEURO.0369-17.2018
VO 5
IS 1
A1 Kucewicz, Michal T.
A1 Berry, Brent M.
A1 Kremen, Vaclav
A1 Miller, Laura R.
A1 Khadjevand, Fatemeh
A1 Ezzyat, Youssef
A1 Stein, Joel M.
A1 Wanda, Paul
A1 Sperling, Michael R.
A1 Gorniak, Richard
A1 Davis, Kathryn A.
A1 Jobst, Barbara C.
A1 Gross, Robert E.
A1 Lega, Bradley
A1 Stead, S. Matt
A1 Rizzuto, Daniel S.
A1 Kahana, Michael J.
A1 Worrell, Gregory A.
YR 2018
UL http://www.eneuro.org/content/5/1/ENEURO.0369-17.2018.abstract
AB Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62–118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with “poor” memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.