TY - JOUR T1 - Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0152-17.2017 VL - 4 IS - 6 SP - ENEURO.0152-17.2017 AU - Prashant K. Srivastava AU - Paolo Roncon AU - Katarzyna Lukasiuk AU - Jan A. Gorter AU - Eleonora Aronica AU - Asla Pitkänen AU - Enrico Petretto AU - Michael R. Johnson AU - Michele Simonato Y1 - 2017/11/01 UR - http://www.eneuro.org/content/4/6/ENEURO.0152-17.2017.abstract N2 - The identification of mechanisms transforming normal to seizure-generating tissue after brain injury is key to developing new antiepileptogenic treatments. MicroRNAs (miRNAs) may act as regulators and potential treatment targets for epileptogenesis. Here, we undertook a meta-analysis of changes in miRNA expression in the hippocampal dentate gyrus (DG) following an epileptogenic insult in three epilepsy models. We identified 26 miRNAs significantly differentially expressed during epileptogenesis, and five differentially expressed in chronic epilepsy. Of these, 13 were not identified in any of the individual studies. To assess the role of these miRNAs, we predicted their mRNA targets and then filtered the list to include only target genes expressed in DG and negatively correlated with miRNA expression. Functional enrichment analysis of mRNA targets of miRNAs dysregulated during epileptogenesis suggested a role for molecular processes related to inflammation and synaptic function. Our results identify new miRNAs associated with epileptogenesis from existing data, highlighting the utility of meta-analysis in maximizing value from preclinical data. ER -