RT Journal Article
SR Electronic
T1 Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0140-17.2017
DO 10.1523/ENEURO.0140-17.2017
VO 4
IS 5
A1 Hamani, Clement
A1 Florence, Gerson
A1 Heinsen, Helmut
A1 Plantinga, Birgit R.
A1 Temel, Yasin
A1 Uludag, Kamil
A1 Alho, Eduardo
A1 Teixeira, Manoel J.
A1 Amaro, Edson
A1 Fonoff, Erich T.
YR 2017
UL http://www.eneuro.org/content/4/5/ENEURO.0140-17.2017.abstract
AB Over the last decades, extensive basic and clinical knowledge has been acquired on the use of subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson’s disease (PD). It is now clear that mechanisms involved in the effects of this therapy are far more complex than previously anticipated. At frequencies commonly used in clinical practice, neural elements may be excited or inhibited and novel dynamic states of equilibrium are reached. Electrode contacts used for chronic DBS in PD are placed near the dorsal border of the nucleus, a highly cellular region. DBS may thus exert its effects by modulating these cells, hyperdirect projections from motor cortical areas, afferent and efferent fibers to the motor STN. Advancements in neuroimaging techniques may allow us to identify these structures optimizing surgical targeting. In this review, we provide an update on mechanisms and the neural elements modulated by STN DBS.