PT - JOURNAL ARTICLE AU - Matthew Alexandar Sarraf AU - Michael Anthony Woodley TI - Of Mice and Men: Empirical Support for the Population-Based Social Epistasis Amplification Model (a Comment on Kalbassi et al., 2017) AID - 10.1523/ENEURO.0280-17.2017 DP - 2017 Aug 31 TA - eneuro PG - ENEURO.0280-17.2017 4099 - http://www.eneuro.org/content/early/2017/08/31/ENEURO.0280-17.2017.short 4100 - http://www.eneuro.org/content/early/2017/08/31/ENEURO.0280-17.2017.full AB - This commentary article offers new perspective on recent research investigating the behavioral and social ecological effects of a mutation related to autism spectrum disorders in mice. The authors explain the consistency of this research on mice with predictions advanced by a theory of the role of interorganismal gene-gene interactions (social epistasis) in social species including humans, known as the social epistasis amplification model. The potential significance of the mouse research for understanding contemporary human behavioral trends is explored.Significance Statement This commentary article offers new perspective on recent research investigating the behavioral and social ecologicalal effects of a mutation related to autism spectrum disorders in mice. The authors explain the consistency of this research on mice with predictions advanced by a theory of the role of interorganismal gene-gene interactions (social epistasis) in social species including humans, known as the social epistasis amplification model. The potential significance of the mouse research for understanding contemporary human behavioral trends is explored.