TY - JOUR T1 - Early-Age Running Enhances Activity of Adult-Born Dentate Granule Neurons Following Learning in Rats JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0237-17.2017 VL - 4 IS - 4 SP - ENEURO.0237-17.2017 AU - Olga Shevtsova AU - Yao-Fang Tan AU - Christina M. Merkley AU - Gordon Winocur AU - J. Martin Wojtowicz Y1 - 2017/07/01 UR - http://www.eneuro.org/content/4/4/ENEURO.0237-17.2017.abstract N2 - Cognitive reserve, the brain’s capacity to draw on enriching experiences during youth, is believed to protect against memory loss associated with a decline in hippocampal function, as seen in normal aging and neurodegenerative disease. Adult neurogenesis has been suggested as a specific mechanism involved in cognitive (or neurogenic) reserve. The first objective of this study was to compare learning–related neuronal activity in adult-born versus developmentally born hippocampal neurons in juvenile male rats that had engaged in extensive running activity during early development or reared in a standard laboratory environment. The second objective was to investigate the long-term effect of exercise in rats on learning and memory of a contextual fear (CF) response later in adulthood. These aims address the important question as to whether exercise in early life is sufficient to build a reserve that protects against the process of cognitive aging. The results reveal a long-term effect of early running on adult-born dentate granule neurons and a special role for adult-born neurons in contextual memory, in a manner that is consistent with the neurogenic reserve hypothesis. ER -