RT Journal Article SR Electronic T1 Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome JF eneuro JO eNeuro FD Society for Neuroscience SP ENEURO.0178-17.2017 DO 10.1523/ENEURO.0178-17.2017 VO 4 IS 4 A1 Albin, Roger L. A1 Minderovic, Christine A1 Koeppe, Robert A. YR 2017 UL http://www.eneuro.org/content/4/4/ENEURO.0178-17.2017.abstract AB Considerable prior work suggests basal ganglia dysfunction in Tourette syndrome (TS). Analysis of a small number of postmortem specimens suggests deficits of some striatal interneuron populations, including striatal cholinergic interneurons. To assess the integrity of striatal cholinergic interneurons in TS, we used [18F]FEOBV positron emission tomography (PET) to quantify striatal vesicular acetylcholine transporter (VAChT) expression, a measure of cholinergic terminal density, in human TS and control subjects. We found no evidence of striatal cholinergic deficits. Discrepant imaging and postmortem analysis results may reflect agonal or postmortem changes, medication effects, or significant disease heterogeneity.