PT - JOURNAL ARTICLE AU - Klingler, Esther TI - Development and Organization of the Evolutionarily Conserved Three-Layered Olfactory Cortex AID - 10.1523/ENEURO.0193-16.2016 DP - 2017 Jan 01 TA - eneuro PG - ENEURO.0193-16.2016 VI - 4 IP - 1 4099 - http://www.eneuro.org/content/4/1/ENEURO.0193-16.2016.short 4100 - http://www.eneuro.org/content/4/1/ENEURO.0193-16.2016.full SO - eNeuro2017 Jan 01; 4 AB - The olfactory cortex is part of the mammalian cerebral cortex together with the neocortex and the hippocampus. It receives direct input from the olfactory bulbs and participates in odor discrimination, association, and learning (Bekkers and Suzuki, 2013). It is thought to be an evolutionarily conserved paleocortex, which shares common characteristics with the three-layered general cortex of reptiles (Aboitiz et al., 2002). The olfactory cortex has been studied as a “simple model” to address sensory processing, though little is known about its precise cell origin, diversity, and identity. While the development and the cellular diversity of the six-layered neocortex are increasingly understood, the olfactory cortex remains poorly documented in these aspects. Here is a review of current knowledge of the development and organization of the olfactory cortex, keeping the analogy with those of the neocortex. The comparison of olfactory cortex and neocortex will allow the opening of evolutionary perspectives on cortical development.