PT  - JOURNAL ARTICLE
AU  - Drion, Guillaume
AU  - Franci, Alessio
AU  - Dethier, Julie
AU  - Sepulchre, Rodolphe
TI  - Dynamic Input Conductances Shape Neuronal Spiking
AID  - 10.1523/ENEURO.0031-14.2015
DP  - 2015 Jan 01
TA  - eneuro
PG  - ENEURO.0031-14.2015
VI  - 2
IP  - 1
4099  - http://www.eneuro.org/content/2/1/ENEURO.0031-14.2015.short
4100  - http://www.eneuro.org/content/2/1/ENEURO.0031-14.2015.full
SO  - eneuro2015 Jan 01; 2
AB  - Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness, and homeostasis of neuronal signalling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current−voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation, and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis.