PT - JOURNAL ARTICLE AU - Crevecoeur, Frédéric AU - Thonnard, Jean-Louis AU - Lefèvre, Philippe AU - Scott, Stephen H. TI - Long-Latency Feedback Coordinates Upper-Limb and Hand Muscles during Object Manipulation Tasks AID - 10.1523/ENEURO.0129-15.2016 DP - 2016 Jan 01 TA - eneuro PG - ENEURO.0129-15.2016 VI - 3 IP - 1 4099 - http://www.eneuro.org/content/3/1/ENEURO.0129-15.2016.short 4100 - http://www.eneuro.org/content/3/1/ENEURO.0129-15.2016.full SO - eneuro2016 Jan 01; 3 AB - Suppose that someone bumps into your arm at a party while you are holding a glass of wine. Motion of the disturbed arm will engage rapid and goal-directed feedback responses in the upper-limb. Although such responses can rapidly counter the perturbation, it is also clearly desirable not to destabilize your grasp and/or spill the wine. Here we investigated how healthy humans maintain a stable grasp following perturbations by using a paradigm that requires spatial tuning of the motor response dependent on the location of a virtual target. Our results highlight a synchronized expression of target-directed feedback in shoulder and hand muscles occurring at ∼60 ms. Considering that conduction delays are longer for the more distal hand muscles, these results suggest that target-directed responses in hand muscles were initiated before those for the shoulder muscles. These results show that long-latency feedback can coordinate upper limb and hand muscles during object manipulation tasks.