RT Journal Article
SR Electronic
T1 Differential Changes in the Lateralized Activity of Identified Projection Neurons of Motor Cortex in Hemiparkinsonian Rats
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0110-19.2019
DO 10.1523/ENEURO.0110-19.2019
VO 6
IS 4
A1 Alain Rios
A1 Shogo Soma
A1 Junichi Yoshida
A1 Satoshi Nonomura
A1 Masanori Kawabata
A1 Yutaka Sakai
A1 Yoshikazu Isomura
YR 2019
UL http://www.eneuro.org/content/6/4/ENEURO.0110-19.2019.abstract
AB In the parkinsonian state, the motor cortex and basal ganglia (BG) undergo dynamic remodeling of movement representation. One such change is the loss of the normal contralateral lateralized activity pattern. The increase in the number of movement-related neurons responding to ipsilateral or bilateral limb movements may cause motor problems, including impaired balance, reduced bimanual coordination, and abnormal mirror movements. However, it remains unknown how individual types of motor cortical neurons organize this reconstruction. To explore the effect of dopamine depletion on lateralized activity in the parkinsonian state, we used a partial hemiparkinsonian model [6-hydroxydopamine (6-OHDA) lesion] in Long–Evans rats performing unilateral movements in a right–left pedal task, while recording from primary (M1) and secondary motor cortex (M2). The lesion decreased contralateral preferred activity in both M1 and M2. In addition, this change differed among identified intratelencephalic (IT) and pyramidal tract (PT) cortical projection neurons, depending on the cortical area. We detected a decrease in lateralized activity only in PT neurons in M1, whereas in M2, this change was observed in IT neurons, with no change in the PT population. Our results suggest a differential effect of dopamine depletion in the lateralized activity of the motor cortex, and suggest possible compensatory changes in the contralateral hemisphere.