RT Journal Article
SR Electronic
T1 Online HD-tRNS Over the Right Temporoparietal Junction Modulates Social Inference But Not Motor Coordination
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0155-25.2025
DO 10.1523/ENEURO.0155-25.2025
VO 12
IS 10
A1 Moreau, Quentin
A1 Chamberland, Vincent
A1 Moses, Lisane
A1 Milanova, Gabriela
A1 Dumas, Guillaume
YR 2025
UL http://www.eneuro.org/content/12/10/ENEURO.0155-25.2025.abstract
AB Social interactions are fundamental to human cognition, with the right temporoparietal junction (rTPJ) playing a key role in integrating motor coordination and social inference. While transcranial random noise stimulation (tRNS) is a promising technique for modulating cortical excitability in real time, its effect on dynamic social processes remains largely unexplored. This study applied high-definition tRNS (HD-tRNS) over the rTPJ during an interactive task to modulate motor coordination and social inference. Eighty neurotypical adults (49 female) were equally distributed across two experiments: Experiment 1, a block design with randomized active and sham stimulation blocks; or Experiment 2, a trial-by-trial design with intermixed stimulation protocols. Participants performed a coordination task with a covert virtual partner programmed to behave cooperatively or competitively. Kinematic data and self-reported attributions of humanness and cooperativeness were analyzed. The results showed that HD-tRNS over the rTPJ did not affect motor coordination or overall task performance in either experiment. However, in Experiment 1, active stimulation progressively reduced attributed humanness and cooperativeness toward the competitive virtual partner, suggesting enhanced detection of antagonistic intent. This gradual modulation of social inference was absent in Experiment 2, where frequent protocol switching likely disrupted the buildup of stimulation effects. Together, these findings highlight the rTPJ's causal role in self–other distinction, underscore the importance of stimulation protocol design in shaping social cognition, and support the exploration of targeted neuromodulation in clinical and developmental populations with atypical social cognition.