RT Journal Article
SR Electronic
T1 Recurrent Interneuron Connectivity Does Not Support Synchrony in a Biophysical Dentate Gyrus Model
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0097-25.2025
DO 10.1523/ENEURO.0097-25.2025
VO 12
IS 4
A1 Müller-Komorowska, Daniel
A1 Fujishige, Temma
A1 Fukai, Tomoki
YR 2025
UL http://www.eneuro.org/content/12/4/ENEURO.0097-25.2025.abstract
AB Synchronous activity of neuronal networks is found in many brain areas and correlates with cognition and behavior. Gamma synchrony is particularly strong in the dentate gyrus, which is thought to process contextual information in the hippocampus. Several network mechanisms for synchrony generation have been proposed and studied computationally. One such mechanism relies solely on recurrent inhibitory interneuron connectivity, but it requires a large enough number of synapses. Here, we incorporate previously published connectivity data of the dentate gyrus from mice of either sex into a biophysical computational model to test its ability to generate synchronous activity. We find that recurrent interneuron connectivity is insufficient to induce synchronous activity. This applies to an interneuron ring network and the broader dentate gyrus circuitry. Despite asynchronous input, recurrent interneuron connectivity can have small synchronizing effects but can also desynchronize the network for some types of synaptic input. Our results suggest that biologically plausible recurrent inhibitory connectivity alone is likely insufficient to synchronize the dentate gyrus.