RT Journal Article
SR Electronic
T1 Astrocytes in the External Globus Pallidus Selectively Represent Routine Formation During Repeated Reward-Seeking in Mice
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0552-24.2025
DO 10.1523/ENEURO.0552-24.2025
VO 12
IS 3
A1 Yang, Minsu Abel
A1 Kang, Shinwoo
A1 Hong, Sa-Ik
A1 Lee, Jeyeon
A1 Bormann, Nicholas L.
A1 Lee, Sang Wan
A1 Choi, Doo-Sup
YR 2025
UL http://www.eneuro.org/content/12/3/ENEURO.0552-24.2025.abstract
AB The external globus pallidus (GPe) is a central part of the basal ganglia indirect pathway implicated in movement and decision-making. As a hub connecting the dorsal striatum and subthalamic nucleus (STN), the GPe guides repetitive and routine behaviors. However, it remains unknown how diverse GPe cells engage in routine formation while learning action sequences in repetitive reward-seeking conditioning. Here, in male mice, we investigated the Ca2+ dynamics of two GPe cell types, astrocytes and parvalbumin-expressing neurons, during routine formation. Our findings show that the dynamics of GPe astrocytes may be involved in action sequence refinement, a characteristic potentially contributing to more efficient reward-seeking behavior.