PT  - JOURNAL ARTICLE
AU  - Yang, Minsu Abel
AU  - Kang, Shinwoo
AU  - Hong, Sa-Ik
AU  - Lee, Jeyeon
AU  - Bormann, Nicholas L.
AU  - Lee, Sang Wan
AU  - Choi, Doo-Sup
TI  - Astrocytes in the External Globus Pallidus Selectively Represent Routine Formation During Repeated Reward-Seeking in Mice
AID  - 10.1523/ENEURO.0552-24.2025
DP  - 2025 Mar 01
TA  - eneuro
PG  - ENEURO.0552-24.2025
VI  - 12
IP  - 3
4099  - http://www.eneuro.org/content/12/3/ENEURO.0552-24.2025.short
4100  - http://www.eneuro.org/content/12/3/ENEURO.0552-24.2025.full
SO  - eNeuro2025 Mar 01; 12
AB  - The external globus pallidus (GPe) is a central part of the basal ganglia indirect pathway implicated in movement and decision-making. As a hub connecting the dorsal striatum and subthalamic nucleus (STN), the GPe guides repetitive and routine behaviors. However, it remains unknown how diverse GPe cells engage in routine formation while learning action sequences in repetitive reward-seeking conditioning. Here, in male mice, we investigated the Ca2+ dynamics of two GPe cell types, astrocytes and parvalbumin-expressing neurons, during routine formation. Our findings show that the dynamics of GPe astrocytes may be involved in action sequence refinement, a characteristic potentially contributing to more efficient reward-seeking behavior.