PT  - JOURNAL ARTICLE
AU  - Zaheer, Fariya
AU  - Levine, Gabriel J.
AU  - Simal, Ana Leticia
AU  - Fatemi Tabatabaei, Seyed Reza
AU  - Martino, Tami A.
AU  - Descalzi, Giannina
TI  - Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and Anxiety-Like Behaviors
AID  - 10.1523/ENEURO.0244-24.2024
DP  - 2025 Feb 01
TA  - eneuro
PG  - ENEURO.0244-24.2024
VI  - 12
IP  - 2
4099  - http://www.eneuro.org/content/12/2/ENEURO.0244-24.2024.short
4100  - http://www.eneuro.org/content/12/2/ENEURO.0244-24.2024.full
SO  - eNeuro2025 Feb 01; 12
AB  - Chronic pain is a debilitative disease affecting one in five adults globally and is a major risk factor for anxiety ( Goldberg and McGee, 2011; Lurie, 2018). Given the current dearth of available treatments for both individuals living with chronic pain and mental illnesses, there is a critical need for research into the molecular mechanisms involved in order to discover novel treatment targets. Cellular homeostasis is crucial for normal bodily functions, and investigations of this process may provide better understanding of the mechanisms driving the development of chronic pain. Using the spared nerve injury (SNI) model of neuropathic pain, we found contrasting roles for BECLIN-1 in the development of pain hypersensitivity and anxiety-like behaviors in a sex-dependent manner. Remarkably, we found that male SNI mice with impaired BECLIN-1 function demonstrated heightened mechanical and thermal hypersensitivity compared with male wild-type SNI mice, while female SNI mice with impaired BECLIN-1 function demonstrated similar thresholds to the female wild-type SNI mice. We also found that disruptions of BECLIN-1 prevented SNI-induced increases in anxiety-like behaviors in male mice. Our data thus indicate that BECLIN-1 is differentially involved in the nociceptive and emotional components of chronic pain in male but not female mice.