RT Journal Article
SR Electronic
T1 The External Globus Pallidus as the Hub of the Auditory Cortico-Basal Ganglia Loop
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0161-24.2024
DO 10.1523/ENEURO.0161-24.2024
VO 11
IS 11
A1 Tomioka, Ryohei
A1 Shigematsu, Naoki
A1 Miyashita, Toshio
A1 Takahashi, Yukie
A1 Yamamoto, Mariko
A1 Yoshimura, Yumiko
A1 Kobayashi, Kenta
A1 Yanagawa, Yuchio
A1 Tamamaki, Nobuaki
A1 Fukuda, Takaichi
A1 Song, Wen-Jie
YR 2024
UL http://www.eneuro.org/content/11/11/ENEURO.0161-24.2024.abstract
AB The cortico-basal ganglia loop has traditionally been conceptualized as consisting of three distinct information networks: motor, limbic, and associative. However, this three-loop concept is insufficient to comprehensively explain the diverse functions of the cortico-basal ganglia system, as emerging evidence suggests its involvement in sensory processing, including the auditory systems. In the present study, we demonstrate the auditory cortico-basal ganglia loop by using transgenic mice and viral-assisted labelings. The caudal part of the external globus pallidus (GPe) emerged as a major output nucleus of the auditory cortico-basal ganglia loop with the cortico-striato-pallidal projections as its input pathway and pallido-cortical and pallido–thalamo–cortical projections as its output pathway. GABAergic neurons in the caudal GPe dominantly innervated the nonlemniscal auditory pathway. They also projected to various regions, including the substantia nigra pars lateralis, cuneiform nucleus, and periaqueductal gray. Considering the functions associated with these GPe-projecting regions, auditory cortico-basal ganglia circuits may play a pivotal role in eliciting defensive behaviors against acoustic stimuli.