RT Journal Article
SR Electronic
T1 The Neural and Computational Architecture of Feedback Dynamics in Mouse Cortex during Stimulus Report
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0191-24.2024
DO 10.1523/ENEURO.0191-24.2024
VO 11
IS 9
A1 Ciceri, Simone
A1 Oude Lohuis, Matthijs N.
A1 Rottschäfer, Vivi
A1 Pennartz, Cyriel M. A.
A1 Avitabile, Daniele
A1 van Gaal, Simon
A1 Olcese, Umberto
YR 2024
UL http://www.eneuro.org/content/11/9/ENEURO.0191-24.2024.abstract
AB Conscious reportability of visual input is associated with a bimodal neural response in the primary visual cortex (V1): an early-latency response coupled to stimulus features and a late-latency response coupled to stimulus report or detection. This late wave of activity, central to major theories of consciousness, is thought to be driven by the prefrontal cortex (PFC), responsible for “igniting” it. Here we analyzed two electrophysiological studies in mice performing different stimulus detection tasks and characterized neural activity profiles in three key cortical regions: V1, posterior parietal cortex (PPC), and PFC. We then developed a minimal network model, constrained by known connectivity between these regions, reproducing the spatiotemporal propagation of visual- and report-related activity. Remarkably, while PFC was indeed necessary to generate report-related activity in V1, this occurred only through the mediation of PPC. PPC, and not PFC, had the final veto in enabling the report-related late wave of V1 activity.