RT Journal Article SR Electronic T1 Frontoparietal Brain Network Plays a Crucial Role in Working Memory Capacity during Complex Cognitive Task JF eneuro JO eNeuro FD Society for Neuroscience SP ENEURO.0394-23.2024 DO 10.1523/ENEURO.0394-23.2024 VO 11 IS 8 A1 Otstavnov, Nikita A1 Nieto-Doval, Carlos A1 Galli, Giulia A1 Feurra, Matteo YR 2024 UL http://www.eneuro.org/content/11/8/ENEURO.0394-23.2024.abstract AB Recent neurophysiological studies provide inconsistent results of frontoparietal network (FPN) stimulation for altering working memory (WM) capacity. This study aimed to boost WM capacity by manipulating the activity of the FPN via dual-site high–definition transcranial direct current stimulation. Forty-eight participants were randomly assigned to three stimulation groups, receiving either simultaneous anodal stimulation of the frontal and parietal areas (double stimulation), or stimulation of the frontal area only (single stimulation), or the placebo stimulation (sham) to frontal and parietal areas. After the stimulation, we used an operation span task to test memory accuracy, mathematical accuracy, time of calculation and memorizing, and recall response time across the three groups. The results revealed an enhancement of memory accuracy and a reduction of time of calculation in the double stimulation group compared with that in others. In addition, recall response time was significantly decreased in the double and single stimulation groups compared with that in sham. No differences in mathematical accuracy were observed. Our results confirm the pivotal role of the FPN in WM and suggest its functional dissociation, with the frontal component more implicated in the retrieval stage and the parietal component in the processing and retention stages.