RT Journal Article
SR Electronic
T1 RhoGEF Tiam2 Regulates Glutamatergic Synaptic Transmission in Hippocampal CA1 Pyramidal Neurons
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0500-21.2024
DO 10.1523/ENEURO.0500-21.2024
VO 11
IS 7
A1 Rao, Sadhna
A1 Liang, Feng
A1 Herring, Bruce E.
YR 2024
UL http://www.eneuro.org/content/11/7/ENEURO.0500-21.2024.abstract
AB Glutamatergic synapses exhibit significant molecular diversity, but circuit-specific mechanisms that underlie synaptic regulation are not well characterized. Prior reports show that Rho-guanine nucleotide exchange factor (RhoGEF) Tiam1 regulates perforant path→dentate gyrus granule neuron synapses. In the present study, we report Tiam1's homolog Tiam2 is implicated in glutamatergic neurotransmission in CA1 pyramidal neurons. We find that Tiam2 regulates evoked excitatory glutamatergic currents via a postsynaptic mechanism mediated by the catalytic Dbl-homology domain. Overall, we present evidence for RhoGEF Tiam2's role in glutamatergic synapse function at Schaffer collateral→CA1 pyramidal neuron synapses.