PT  - JOURNAL ARTICLE
AU  - Rao, Sadhna
AU  - Liang, Feng
AU  - Herring, Bruce E.
TI  - RhoGEF Tiam2 Regulates Glutamatergic Synaptic Transmission in Hippocampal CA1 Pyramidal Neurons
AID  - 10.1523/ENEURO.0500-21.2024
DP  - 2024 Jul 01
TA  - eneuro
PG  - ENEURO.0500-21.2024
VI  - 11
IP  - 7
4099  - http://www.eneuro.org/content/11/7/ENEURO.0500-21.2024.short
4100  - http://www.eneuro.org/content/11/7/ENEURO.0500-21.2024.full
SO  - eNeuro2024 Jul 01; 11
AB  - Glutamatergic synapses exhibit significant molecular diversity, but circuit-specific mechanisms that underlie synaptic regulation are not well characterized. Prior reports show that Rho-guanine nucleotide exchange factor (RhoGEF) Tiam1 regulates perforant path→dentate gyrus granule neuron synapses. In the present study, we report Tiam1's homolog Tiam2 is implicated in glutamatergic neurotransmission in CA1 pyramidal neurons. We find that Tiam2 regulates evoked excitatory glutamatergic currents via a postsynaptic mechanism mediated by the catalytic Dbl-homology domain. Overall, we present evidence for RhoGEF Tiam2's role in glutamatergic synapse function at Schaffer collateral→CA1 pyramidal neuron synapses.