RT Journal Article
SR Electronic
T1 Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0021-24.2024
DO 10.1523/ENEURO.0021-24.2024
VO 11
IS 6
A1 Zhang, Xuyang
A1 Zhang, Qingzhu
A1 Zhang, Qian
A1 Wang, Haomiao
A1 Yin, Yi
A1 Li, Huanhuan
A1 Huang, Qianying
A1 Guo, Chao
A1 Zhong, Jun
A1 Zhou, Tengyuan
A1 Chen, Yujie
A1 Chen, Zhi
A1 Shan, Qiao
A1 Hu, Rong
YR 2024
UL http://www.eneuro.org/content/11/6/ENEURO.0021-24.2024.abstract
AB Intracerebral hemorrhage (ICH), the most common subtype of hemorrhagic stroke, leads to cognitive impairment and imposes significant psychological burdens on patients. Hippocampal neurogenesis has been shown to play an essential role in cognitive function. Our previous study has shown that tetrahydrofolate (THF) promotes the proliferation of neural stem cells (NSCs). However, the effect of THF on cognition after ICH and the underlying mechanisms remain unclear. Here, we demonstrated that administration of THF could restore cognition after ICH. Using Nestin-GFP mice, we further revealed that THF enhanced the proliferation of hippocampal NSCs and neurogenesis after ICH. Mechanistically, we found that THF could prevent ICH-induced elevated level of PTEN and decreased expressions of phosphorylated AKT and mTOR. Furthermore, conditional deletion of PTEN in NSCs of the hippocampus attenuated the inhibitory effect of ICH on the proliferation of NSCs and abnormal neurogenesis. Taken together, these results provide molecular insights into ICH-induced cognitive impairment and suggest translational clinical therapeutic strategy for hemorrhagic stroke.