PT - JOURNAL ARTICLE AU - Waguespack, Hannah F. AU - Jacobs, Jessica T. AU - Park, Janis AU - Campos-Rodriguez, Carolina AU - Maior, Rafael S. AU - Forcelli, Patrick A. AU - Malkova, Ludise TI - Pharmacological Inhibition of the Nucleus Accumbens Increases Dyadic Social Interaction in Macaques AID - 10.1523/ENEURO.0085-24.2024 DP - 2024 Apr 01 TA - eneuro PG - ENEURO.0085-24.2024 VI - 11 IP - 4 4099 - http://www.eneuro.org/content/11/4/ENEURO.0085-24.2024.short 4100 - http://www.eneuro.org/content/11/4/ENEURO.0085-24.2024.full SO - eNeuro2024 Apr 01; 11 AB - The nucleus accumbens (NAc) is a central component of the brain circuitry that mediates motivated behavior, including reward processing. Since the rewarding properties of social stimuli have a vital role in guiding behavior (both in humans and nonhuman animals), the NAc is likely to contribute to the brain circuitry controlling social behavior. In rodents, prior studies have found that focal pharmacological inhibition of NAc and/or elevation of dopamine in NAc increases social interactions. However, the role of the NAc in social behavior in nonhuman primates remains unknown. We measured the social behavior of eight dyads of male macaques following (1) pharmacological inhibition of the NAc using the GABAA agonist muscimol and (2) focal application of quinpirole, an agonist at the D2 family of dopamine receptors. Transient inhibition of the NAc with muscimol increased social behavior when drug was infused in submissive, but not dominant partners of the dyad. Focal application of quinpirole was without effect on social behavior when infused into the NAc of either dominant or submissive subjects. Our data demonstrate that the NAc contributes to social interactions in nonhuman primates.