RT Journal Article
SR Electronic
T1 Helium Optically Pumped Magnetometers Can Detect Epileptic Abnormalities as Well as SQUIDs as Shown by Intracerebral Recordings
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0222-23.2023
DO 10.1523/ENEURO.0222-23.2023
VO 10
IS 12
A1 Badier, Jean-Michel
A1 Schwartz, Denis
A1 Bénar, Christian-George
A1 Kanzari, Khoubeib
A1 Daligault, Sébastien
A1 Romain, Rudy
A1 Mitryukovskiy, Sergey
A1 Fourcault, William
A1 Josselin, Vincent
A1 Le Prado, Matthieu
A1 Jung, Julien
A1 Palacios-Laloy, Augustin
A1 Romain, Carron
A1 Bartolomei, Fabrice
A1 Labyt, Etienne
A1 Bonini, Francesca
YR 2023
UL http://www.eneuro.org/content/10/12/ENEURO.0222-23.2023.abstract
AB Magnetoencephalography based on superconducting quantum interference devices (SQUIDs) has been shown to improve the diagnosis and surgical treatment decision for presurgical evaluation of drug-resistant epilepsy. Still, its use remains limited because of several constraints such as cost, fixed helmet size, and the obligation of immobility. A new generation of sensors, optically pumped magnetometers (OPMs), could overcome these limitations. In this study, we validate the ability of helium-based OPM (4He-OPM) sensors to record epileptic brain activity thanks to simultaneous recordings with intracerebral EEG [stereotactic EEG (SEEG)]. We recorded simultaneous SQUIDs-SEEG and 4He-OPM-SEEG signals in one patient during two sessions. We show that epileptic activities on intracerebral EEG can be recorded by OPMs with a better signal-to noise ratio than classical SQUIDs. The OPM sensors open new venues for the widespread application of magnetoencephalography in the management of epilepsy and other neurologic diseases and fundamental neuroscience.