PT  - JOURNAL ARTICLE
AU  - Badier, Jean-Michel
AU  - Schwartz, Denis
AU  - Bénar, Christian-George
AU  - Kanzari, Khoubeib
AU  - Daligault, Sébastien
AU  - Romain, Rudy
AU  - Mitryukovskiy, Sergey
AU  - Fourcault, William
AU  - Josselin, Vincent
AU  - Le Prado, Matthieu
AU  - Jung, Julien
AU  - Palacios-Laloy, Augustin
AU  - Romain, Carron
AU  - Bartolomei, Fabrice
AU  - Labyt, Etienne
AU  - Bonini, Francesca
TI  - Helium Optically Pumped Magnetometers Can Detect Epileptic Abnormalities as Well as SQUIDs as Shown by Intracerebral Recordings
AID  - 10.1523/ENEURO.0222-23.2023
DP  - 2023 Dec 01
TA  - eneuro
PG  - ENEURO.0222-23.2023
VI  - 10
IP  - 12
4099  - http://www.eneuro.org/content/10/12/ENEURO.0222-23.2023.short
4100  - http://www.eneuro.org/content/10/12/ENEURO.0222-23.2023.full
SO  - eNeuro2023 Dec 01; 10
AB  - Magnetoencephalography based on superconducting quantum interference devices (SQUIDs) has been shown to improve the diagnosis and surgical treatment decision for presurgical evaluation of drug-resistant epilepsy. Still, its use remains limited because of several constraints such as cost, fixed helmet size, and the obligation of immobility. A new generation of sensors, optically pumped magnetometers (OPMs), could overcome these limitations. In this study, we validate the ability of helium-based OPM (4He-OPM) sensors to record epileptic brain activity thanks to simultaneous recordings with intracerebral EEG [stereotactic EEG (SEEG)]. We recorded simultaneous SQUIDs-SEEG and 4He-OPM-SEEG signals in one patient during two sessions. We show that epileptic activities on intracerebral EEG can be recorded by OPMs with a better signal-to noise ratio than classical SQUIDs. The OPM sensors open new venues for the widespread application of magnetoencephalography in the management of epilepsy and other neurologic diseases and fundamental neuroscience.