RT Journal Article
SR Electronic
T1 Multimodal Temporal Pattern Discrimination Is Encoded in Visual Cortical Dynamics
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0047-23.2023
DO 10.1523/ENEURO.0047-23.2023
VO 10
IS 7
A1 Post, Sam
A1 Mol, William
A1 Abu-Wishah, Omar
A1 Ali, Shazia
A1 Rahmatullah, Noorhan
A1 Goel, Anubhuti
YR 2023
UL http://www.eneuro.org/content/10/7/ENEURO.0047-23.2023.abstract
AB Discriminating between temporal features in sensory stimuli is critical to complex behavior and decision-making. However, how sensory cortical circuit mechanisms contribute to discrimination between subsecond temporal components in sensory events is unclear. To elucidate the mechanistic underpinnings of timing in primary visual cortex (V1), we recorded from V1 using two-photon calcium imaging in awake-behaving mice performing a go/no-go discrimination timing task, which was composed of patterns of subsecond audiovisual stimuli. In both conditions, activity during the early stimulus period was temporally coordinated with the preferred stimulus. However, while network activity increased in the preferred condition, network activity was increasingly suppressed in the nonpreferred condition over the stimulus period. Multiple levels of analyses suggest that discrimination between subsecond intervals that are contained in rhythmic patterns can be accomplished by local neural dynamics in V1.