RT Journal Article
SR Electronic
T1 The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0242-22.2023
DO 10.1523/ENEURO.0242-22.2023
VO 10
IS 4
A1 Tissink, Elleke
A1 Werme, Josefin
A1 de Lange, Siemon C.
A1 Savage, Jeanne E.
A1 Wei, Yongbin
A1 de Leeuw, Christiaan A.
A1 Nagel, Mats
A1 Posthuma, Danielle
A1 van den Heuvel, Martijn P.
YR 2023
UL http://www.eneuro.org/content/10/4/ENEURO.0242-22.2023.abstract
AB Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC is heritable and partially translates to the anatomic architecture of white matter, but the genetic component of structural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remain unknown. Here, we perform genome-wide association studies (Ndiscovery = 24,336; Nreplication = 3412) and annotation on RSN-SC and RSN-FC. We identify genes for visual network-SC that are involved in axon guidance and synaptic functioning. Genetic variation in RSN-FC impacts biological processes relevant to brain disorders that previously were only phenotypically associated with RSN-FC alterations. Correlations of the genetic components of RSNs are mostly observed within the functional domain, whereas less overlap is observed within the structural domain and between the functional and structural domains. This study advances the understanding of the complex functional organization of the brain and its structural underpinnings from a genetics viewpoint.