RT Journal Article
SR Electronic
T1 BrainWAVE: A Flexible Method for Noninvasive Stimulation of Brain Rhythms across Species
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0257-22.2022
DO 10.1523/ENEURO.0257-22.2022
VO 10
IS 2
A1 Attokaren, Matthew K.
A1 Jeong, Nuri
A1 Blanpain, Lou
A1 Paulson, Abigail L.
A1 Garza, Kristie M.
A1 Borron, Ben
A1 Walelign, Michael
A1 Willie, Jon
A1 Singer, Annabelle C.
YR 2023
UL http://www.eneuro.org/content/10/2/ENEURO.0257-22.2022.abstract
AB Rhythmic neural activity, which coordinates brain regions and neurons to achieve multiple brain functions, is impaired in many diseases. Despite the therapeutic potential of driving brain rhythms, methods to noninvasively target deep brain regions are limited. Accordingly, we recently introduced a noninvasive stimulation approach using flickering lights and sounds (“flicker”). Flicker drives rhythmic activity in deep and superficial brain regions. Gamma flicker spurs immune function, clears pathogens, and rescues memory performance in mice with amyloid pathology. Here, we present substantial improvements to this approach that is flexible, user-friendly, and generalizable across multiple experimental settings and species. We present novel open-source methods for flicker stimulation across rodents and humans. We demonstrate rapid, cross-species induction of rhythmic activity without behavioral confounds in multiple settings from electrophysiology to neuroimaging. This flicker approach provides an exceptional opportunity to discover the therapeutic effects of brain rhythms across scales and species.