PT  - JOURNAL ARTICLE
AU  - Gracia-Tabuenca, Zeus
AU  - Díaz-Patiño, Juan Carlos
AU  - Arelio-Ríos, Isaac
AU  - Moreno-García, Martha Beatriz
AU  - Barrios, Fernando A.
AU  - Alcauter, Sarael
TI  - Development of the Functional Connectome Topology in Adolescence: Evidence from Topological Data Analysis
AID  - 10.1523/ENEURO.0296-21.2022
DP  - 2023 Feb 01
TA  - eneuro
PG  - ENEURO.0296-21.2022
VI  - 10
IP  - 2
4099  - http://www.eneuro.org/content/10/2/ENEURO.0296-21.2022.short
4100  - http://www.eneuro.org/content/10/2/ENEURO.0296-21.2022.full
SO  - eNeuro2023 Feb 01; 10
AB  - Adolescence is a crucial developmental period in terms of behavior and mental health. Therefore, understanding how the brain develops during this stage is a fundamental challenge for neuroscience. Recent studies have modeled the brain as a network or connectome, mainly applying measures from graph theory, showing a change in its functional organization, such as an increase in its segregation and integration. Topological Data Analysis (TDA) complements such modeling by extracting high-dimensional features across the whole range of connectivity values instead of exploring a fixed set of connections. This study inquires into the developmental trajectories of such properties using a longitudinal sample of typically developing human participants (N = 98; 53/45 female/male; 6.7–18.1 years), applying TDA to their functional connectomes. In addition, we explore the effect of puberty on individual developmental trajectories. Results showed that the adolescent brain has a more distributed topology structure compared with random networks but is more densely connected at the local level. Furthermore, developmental effects showed nonlinear trajectories for the topology of the whole brain and fronto-parietal networks, with an inflection point and increasing trajectories after puberty onset. These results add to the insights into the development of the functional organization of the adolescent brain.