PT  - JOURNAL ARTICLE
AU  - Cȋrneci, Dragoş
AU  - Onu, Mihaela
AU  - Papasteri, Claudiu C.
AU  - Georgescu, Dana
AU  - Poalelungi, Cătălina
AU  - Sofonea, Alexandra
AU  - Puşcaşu, Nicoleta
AU  - Tanase, Dumitru
AU  - Rădeanu, Teofila
AU  - Toader, Maria-Yaelle
AU  - Dogaru, Andreea L.
AU  - Podină, Ioana R.
AU  - Berceanu, Alexandru I.
AU  - Carcea, Ioana
TI  - Neural Networks Implicated in Autobiographical Memory Training
AID  - 10.1523/ENEURO.0137-22.2022
DP  - 2022 Nov 01
TA  - eneuro
PG  - ENEURO.0137-22.2022
VI  - 9
IP  - 6
4099  - http://www.eneuro.org/content/9/6/ENEURO.0137-22.2022.short
4100  - http://www.eneuro.org/content/9/6/ENEURO.0137-22.2022.full
SO  - eNeuro2022 Nov 01; 9
AB  - Training of autobiographical memory has been proposed as an intervention to improve cognitive function. The neural substrates for such improvements are poorly understood. Several brain areas have been previously linked to autobiographical recollection, including structures in the default mode network (DMN) and the sensorimotor network. Here, we tested the hypothesis that changes in connectivity within different neural networks support distinct aspects of memory improvement in response to training on a group of 59 human subjects. We found that memory training using olfactory cues increases resting-state intranetwork DMN connectivity, and this associates with improved recollection of cue-specific memories. On the contrary, training decreased resting-state connectivity within the sensorimotor network, a decrease that correlated with improved ability for voluntary recall. Moreover, preliminary data indicate that only the decrease in sensorimotor connectivity associated with the training-induced decrease in the tumor necrosis factor α (TNFα) factor, an immune modulation previously linked to improved cognitive performance. We identified functional and biochemical factors that associate with distinct memory processes improved by autobiographical training. Pathways which connect autobiographical memory with both high-level cognition and somatic physiology are discussed.