PT  - JOURNAL ARTICLE
AU  - Nathan Godfrey
AU  - Kehan Chen
AU  - Temoor Tayyab
AU  - Gina Dimitropoulos
AU  - Frank P. MacMaster
AU  - Stephanie L. Borgland
TI  - Development of an Open Face Home Cage Running Wheel for Testing Activity-Based Anorexia and Other Applications
AID  - 10.1523/ENEURO.0246-22.2022
DP  - 2022 Sep 01
TA  - eneuro
PG  - ENEURO.0246-22.2022
VI  - 9
IP  - 5
4099  - http://www.eneuro.org/content/9/5/ENEURO.0246-22.2022.short
4100  - http://www.eneuro.org/content/9/5/ENEURO.0246-22.2022.full
SO  - eNeuro2022 Sep 01; 9
AB  - Running wheels for mice residing in the home cage are useful for the continuous measurement of locomotor activity for studies testing exercise interventions or exercise-induced effects on brain and metabolism. Here, we have developed an open source, printable, open-faced running wheel that is automated to collect locomotor information such as distance traveled, wheel direction, and velocity that can be binned into epochs over 24 h or multiple days. This system allows for remote data collection to avoid human interference in mouse behavioral experiments. We tested this system in an activity-based anorexia procedure. Using these wheels, we replicate previous findings that food restriction augments wheel-running activity.