<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dovek, Laura</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Remind Me, My Memory Is All Shook Up</style></title><secondary-title><style face="normal" font="default" size="100%">eneuro</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2022-09-01 00:00:00</style></date></pub-dates></dates><elocation-id><style  face="normal" font="default" size="100%">ENEURO.0379-22.2022</style></elocation-id><doi><style  face="normal" font="default" size="100%">10.1523/ENEURO.0379-22.2022</style></doi><volume><style face="normal" font="default" size="100%">9</style></volume><issue><style face="normal" font="default" size="100%">5</style></issue><abstract><style  face="normal" font="default" size="100%">Our brains synthesize vast and varied sensory inputs to represent an event or place that can later be recalled freely. The term “engram” refers to a group of neurons activated in association with a memory or event, suggesting that if one were to activate a subset of cells in the ensemble, one would trigger the recall of a memory. The medial temporal lobes, including the hippocampus, are often studied as the primary region of spatial engram formation (Josselyn and Tonegawa, 2020). However, newly formed spatial memory representations are incredibly transient. Following encoding, consolidation from the hippocampus to related cortical structures is critical for stable memory retention (Wirt and Hyman, 2017). What happens when this process of generating stable long-term memories is disrupted? Neuronal hyperactivity, seen in seizures, potentially corrupts existing engrams and is often associated with retrograde amnesia in humans. Retrograde amnesia, or forgetting recently formed memories, could be because of disruptions in memories being transferred from the hippocampus to cortical structures. Circuits in the hippocampal dentate gyrus (DG), proposed to support memory consolidation, act as an alternative route for seizure spread from the hippocampus to the neocortex, raising the possibility that unstructured activity in seizures may degrade the structured process of memory formation (Dabrowska et al., 2019). This intriguing possibility is explored in the study by …</style></abstract></record></records></xml>