RT Journal Article
SR Electronic
T1 A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0491-21.2022
DO 10.1523/ENEURO.0491-21.2022
VO 9
IS 5
A1 Mahdi Ramadan
A1 Eric Kenji Lee
A1 Saskia de Vries
A1 Shiella Caldejon
A1 India Kato
A1 Kate Roll
A1 Fiona Griffin
A1 Thuyanh V. Nguyen
A1 Josh Larkin
A1 Paul Rhoads
A1 Kyla Mace
A1 Ali Kriedberg
A1 Robert Howard
A1 Nathan Berbesque
A1 Jérôme Lecoq
YR 2022
UL http://www.eneuro.org/content/9/5/ENEURO.0491-21.2022.abstract
AB Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior signals are broadcast to different layers and areas of the visual cortex. To do so, we leveraged a standardized and spontaneous behavioral fidget event in passively viewing mice. Importantly, this behavior event had no relevance to any ongoing task allowing us to compare its neuronal correlates with visually relevant behaviors (e.g., running). A large two-photon Ca2+ imaging database of neuronal responses uncovered four neural response types during fidgets that were consistent in their proportion and response patterns across all visual areas and layers of the visual cortex. Indeed, the layer and area identity could not be decoded above chance level based only on neuronal recordings. In contrast to running behavior, fidget evoked neural responses that were independent to visual processing. The broad availability of visually orthogonal standardized behavior signals could be a key component in how the cortex selects, learns and binds local sensory information with motor outputs. Contrary to behaviorally relevant motor outputs, irrelevant motor signals could project to separate local neural subspaces.