TY - JOUR T1 - A Standardized Nonvisual Behavioral Event Is Broadcasted Homogeneously across Cortical Visual Areas without Modulating Visual Responses JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0491-21.2022 VL - 9 IS - 5 SP - ENEURO.0491-21.2022 AU - Mahdi Ramadan AU - Eric Kenji Lee AU - Saskia de Vries AU - Shiella Caldejon AU - India Kato AU - Kate Roll AU - Fiona Griffin AU - Thuyanh V. Nguyen AU - Josh Larkin AU - Paul Rhoads AU - Kyla Mace AU - Ali Kriedberg AU - Robert Howard AU - Nathan Berbesque AU - Jérôme Lecoq Y1 - 2022/09/01 UR - http://www.eneuro.org/content/9/5/ENEURO.0491-21.2022.abstract N2 - Multiple recent studies have shown that motor activity greatly impacts the activity of primary sensory areas like V1. Yet, the role of this motor related activity in sensory processing is still unclear. Here, we dissect how these behavior signals are broadcast to different layers and areas of the visual cortex. To do so, we leveraged a standardized and spontaneous behavioral fidget event in passively viewing mice. Importantly, this behavior event had no relevance to any ongoing task allowing us to compare its neuronal correlates with visually relevant behaviors (e.g., running). A large two-photon Ca2+ imaging database of neuronal responses uncovered four neural response types during fidgets that were consistent in their proportion and response patterns across all visual areas and layers of the visual cortex. Indeed, the layer and area identity could not be decoded above chance level based only on neuronal recordings. In contrast to running behavior, fidget evoked neural responses that were independent to visual processing. The broad availability of visually orthogonal standardized behavior signals could be a key component in how the cortex selects, learns and binds local sensory information with motor outputs. Contrary to behaviorally relevant motor outputs, irrelevant motor signals could project to separate local neural subspaces. ER -