RT Journal Article
SR Electronic
T1 Dynamics and Potential Significance of Spontaneous Activity in the Habenula
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0287-21.2022
DO 10.1523/ENEURO.0287-21.2022
VO 9
IS 5
A1 Suryadi
A1 Ruey-Kuang Cheng
A1 Elliot Birkett
A1 Suresh Jesuthasan
A1 Lock Yue Chew
YR 2022
UL http://www.eneuro.org/content/9/5/ENEURO.0287-21.2022.abstract
AB The habenula is an evolutionarily conserved structure of the vertebrate brain that is essential for behavioral flexibility and mood control. It is spontaneously active and is able to access diverse states when the animal is exposed to sensory stimuli. Here we investigate the dynamics of habenula spontaneous activity, to gain insight into how sensitivity is optimized. Two-photon calcium imaging was performed in resting zebrafish larvae at single-cell resolution. An analysis of avalanches of inferred spikes suggests that the habenula is subcritical. Activity had low covariance and a small mean, arguing against dynamic criticality. A multiple regression estimator of autocorrelation time suggests that the habenula is neither fully asynchronous nor perfectly critical, but is reverberating. This pattern of dynamics may enable integration of information and high flexibility in the tuning of network properties, thus providing a potential mechanism for the optimal responses to a changing environment.