RT Journal Article SR Electronic T1 Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus JF eneuro JO eNeuro FD Society for Neuroscience SP ENEURO.0076-22.2022 DO 10.1523/ENEURO.0076-22.2022 VO 9 IS 4 A1 Liana Melo-Thomas A1 Lars Tacken A1 Nicole Richter A1 Davina de Almeida A1 Catarina RapĂ´so A1 Silvana Regina de Melo A1 Uwe Thomas A1 Yara Bezerra de Paiva A1 Priscila Medeiros A1 Norberto Cysne Coimbra A1 Rainer Schwarting YR 2022 UL http://www.eneuro.org/content/9/4/ENEURO.0076-22.2022.abstract AB After unilateral lesion of the medial forebrain bundle by 6-OHDA rats exhibit lateralized deficits in spontaneous behavior or apomorphine-induced rotations. We investigated whether such lateralization is attenuated by either deep brain stimulation (DBS) or glutamatergic neurotransmission in the inferior colliculus (IC) of Wistar rats. Intracollicular DBS did not affect spontaneous lateralization but attenuated apomorphine-induced rotations. Spontaneous lateralization disappeared after either the glutamatergic antagonist MK-801 or the agonist NMDA microinjections into the IC. Apomorphine-induced rotations were potentiated by MK-801 but were not affected by NMDA intracollicular microinjection. After injecting a bidirectional neural tract tracer into the IC, cell bodies and/or axonal fibers were found in the periaqueductal gray matter, superior colliculus, substantia nigra, cuneiform nucleus, and pedunculo-pontine tegmental nucleus, suggesting the involvement of these structures in the motor improvement after IC manipulation. Importantly, the side of the IC microinjection regarding the lesion (ipsilateral or contralateral) is particularly important, and this effect may not involve the neostriatum directly.