RT Journal Article
SR Electronic
T1 Sex Differences in the Alcohol-Mediated Modulation of BLA Network States
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0010-22.2022
DO 10.1523/ENEURO.0010-22.2022
VO 9
IS 4
A1 Alyssa DiLeo
A1 Pantelis Antonoudiou
A1 Spencer Ha
A1 Jamie L. Maguire
YR 2022
UL http://www.eneuro.org/content/9/4/ENEURO.0010-22.2022.abstract
AB Alcohol use, reported by 85% of adults in the United States, is highly comorbid with mood disorders, like generalized anxiety disorder and major depression. The basolateral amygdala (BLA) is an area of the brain that is heavily implicated in both mood disorders and alcohol use disorder. Importantly, the modulation of BLA network/oscillatory states via parvalbumin (PV)-positive GABAergic interneurons has been shown to control the behavioral expression of fear and anxiety. Further, PV interneurons express a high density of δ subunit-containing GABAA receptors (GABAARs), which are sensitive to low concentrations of alcohol. Therefore, we hypothesized that the effects of alcohol may modulate BLA network states that have been associated with fear and anxiety behaviors via δ-GABAARs on PV interneurons in the BLA. Given the impact of ovarian hormones on the expression of δ-GABAARs, we also examined the ability of alcohol to modulate local field potentials in the BLA from male and female C57BL/6J and Gabrd−/− mice after acute and repeated exposure to alcohol. Here, we demonstrate that acute and repeated alcohol can differentially modulate oscillatory states in male and female C57BL/6J mice, a process that involves δ-GABAARs. This is the first study to demonstrate that alcohol is capable of altering network states implicated in both anxiety and alcohol use disorders.