RT Journal Article
SR Electronic
T1 Recording Synaptic Transmission from Auditory Mixed Synapses on the Mauthner Cells of Developing Zebrafish
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0021-22.2022
DO 10.1523/ENEURO.0021-22.2022
VO 9
IS 3
A1 Fabio A. Echeverry
A1 Sundas Ijaz
A1 Alberto E. Pereda
YR 2022
UL http://www.eneuro.org/content/9/3/ENEURO.0021-22.2022.abstract
AB The Mauthner cells are a pair of large reticulospinal neurons that organize sensory-evoked tail flip responses in fishes. An identifiable group of auditory “mixed” (electrical and chemical) synaptic contacts known as “Large Myelinated Club endings” on these cells have provided a valuable model for the study of synaptic transmission in the vertebrate brain. While most of studies were performed in adult fish, we describe here methods that make possible recording synaptic transmission from these contacts in developing zebrafish, a genetically tractable vertebrate species which is uniquely amenable for combining synaptic physiology with live imaging and behavioral analysis.