PT  - JOURNAL ARTICLE
AU  - Fabio A. Echeverry
AU  - Sundas Ijaz
AU  - Alberto E. Pereda
TI  - Recording Synaptic Transmission from Auditory Mixed Synapses on the Mauthner Cells of Developing Zebrafish
AID  - 10.1523/ENEURO.0021-22.2022
DP  - 2022 May 01
TA  - eneuro
PG  - ENEURO.0021-22.2022
VI  - 9
IP  - 3
4099  - http://www.eneuro.org/content/9/3/ENEURO.0021-22.2022.short
4100  - http://www.eneuro.org/content/9/3/ENEURO.0021-22.2022.full
SO  - eNeuro2022 May 01; 9
AB  - The Mauthner cells are a pair of large reticulospinal neurons that organize sensory-evoked tail flip responses in fishes. An identifiable group of auditory “mixed” (electrical and chemical) synaptic contacts known as “Large Myelinated Club endings” on these cells have provided a valuable model for the study of synaptic transmission in the vertebrate brain. While most of studies were performed in adult fish, we describe here methods that make possible recording synaptic transmission from these contacts in developing zebrafish, a genetically tractable vertebrate species which is uniquely amenable for combining synaptic physiology with live imaging and behavioral analysis.