PT  - JOURNAL ARTICLE
AU  - Ada J. Ellingsrud
AU  - Didrik B. Dukefoss
AU  - Rune Enger
AU  - Geir Halnes
AU  - Klas Pettersen
AU  - Marie E. Rognes
TI  - Validating a Computational Framework for Ionic Electrodiffusion with Cortical Spreading Depression as a Case Study
AID  - 10.1523/ENEURO.0408-21.2022
DP  - 2022 Mar 01
TA  - eneuro
PG  - ENEURO.0408-21.2022
VI  - 9
IP  - 2
4099  - http://www.eneuro.org/content/9/2/ENEURO.0408-21.2022.short
4100  - http://www.eneuro.org/content/9/2/ENEURO.0408-21.2022.full
SO  - eNeuro2022 Mar 01; 9
AB  - Cortical spreading depression (CSD) is a wave of pronounced depolarization of brain tissue accompanied by substantial shifts in ionic concentrations and cellular swelling. Here, we validate a computational framework for modeling electrical potentials, ionic movement, and cellular swelling in brain tissue during CSD. We consider different model variations representing wild-type (WT) or knock-out/knock-down mice and systematically compare the numerical results with reports from a selection of experimental studies. We find that the data for several CSD hallmarks obtained computationally, including wave propagation speed, direct current shift duration, peak in extracellular K+ concentration as well as a pronounced shrinkage of extracellular space (ECS) are well in line with what has previously been observed experimentally. Further, we assess how key model parameters including cellular diffusivity, structural ratios, membrane water and/or K+ permeabilities affect the set of CSD characteristics.