PT - JOURNAL ARTICLE AU - Aaron L. Wong AU - Audrey L. Green AU - Mitchell W. Isaacs TI - Motor Plans under Uncertainty Reflect a Trade-Off between Maximizing Reward and Success AID - 10.1523/ENEURO.0503-21.2022 DP - 2022 Mar 01 TA - eneuro PG - ENEURO.0503-21.2022 VI - 9 IP - 2 4099 - http://www.eneuro.org/content/9/2/ENEURO.0503-21.2022.short 4100 - http://www.eneuro.org/content/9/2/ENEURO.0503-21.2022.full SO - eNeuro2022 Mar 01; 9 AB - When faced with multiple potential movement options, individuals either reach directly to one of the options, or initiate a reach intermediate between the options. It remains unclear why people generate these two types of behaviors. Using the go-before-you-know task (commonly used to study behavior under choice uncertainty) in humans, we examined two key questions. First, do these two types of responses actually reflect distinct movement strategies? If so, the relative desirability (i.e., weighing the success likelihood vs the attainable reward) of the two target options would not need to be computed identically for direct and intermediate reaches. We showed that indeed, when reward and success likelihood differed between the two options, reach direction was preferentially biased toward different directions for direct versus intermediate reaches. Importantly, this suggests that the computation of subjective values depends on the choice of movement strategy. Second, what drives individual differences in how people respond under uncertainty? We found that risk/reward-seeking individuals tended to generate more intermediate reaches and were more responsive to changes in reward, suggesting these movements may reflect a strategy to maximize reward versus success. Together, these findings suggest that when faced with choice uncertainty, individuals adopt movement strategies consistent with their risk/reward attitude, preferentially biasing behavior toward exogenous rewards or endogenous success and consequently modulating the relative desirability of the available options.