PT - JOURNAL ARTICLE AU - Balbir Singh AU - Xue-Lian Qi AU - David T. Blake AU - Christos Constantinidis TI - Rhythmicity of Prefrontal Local Field Potentials after Nucleus Basalis Stimulation AID - 10.1523/ENEURO.0380-21.2022 DP - 2022 Jan 01 TA - eneuro PG - ENEURO.0380-21.2022 VI - 9 IP - 1 4099 - http://www.eneuro.org/content/9/1/ENEURO.0380-21.2022.short 4100 - http://www.eneuro.org/content/9/1/ENEURO.0380-21.2022.full SO - eNeuro2022 Jan 01; 9 AB - The action of acetylcholine in the cortex is critical for cognitive functions and cholinergic drugs can improve functions such as attention and working memory. An alternative means of enhancing cholinergic neuromodulation in primates is the intermittent electrical stimulation of the cortical source of acetylcholine, the nucleus basalis (NB) of Meynert. NB stimulation generally increases firing rate of neurons in the prefrontal cortex, however its effects on single neurons are diverse and complex. We sought to understand how NB stimulation affects global measures of neural activity by recording and analyzing local field potentials (LFPs) in monkeys as they performed working memory tasks. NB stimulation primarily decreased power in the alpha frequency range during the delay interval of working memory tasks. The effect was consistent across variants of the task. No consistent modulation in the delay interval of the task was observed in the gamma frequency range, which has previously been implicated in the maintenance of working memory. Our results reveal global effects of cholinergic neuromodulation via deep brain stimulation, an emerging intervention for the improvement of cognitive function.