<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Engelhardt, Clara</style></author><author><style face="normal" font="default" size="100%">Tang, Fiona</style></author><author><style face="normal" font="default" size="100%">Elkhateib, Radwa</style></author><author><style face="normal" font="default" size="100%">Bordes, Joeri</style></author><author><style face="normal" font="default" size="100%">Brix, Lea Maria</style></author><author><style face="normal" font="default" size="100%">van Doeselaar, Lotte</style></author><author><style face="normal" font="default" size="100%">Häusl, Alexander S.</style></author><author><style face="normal" font="default" size="100%">Pöhlmann, Max L.</style></author><author><style face="normal" font="default" size="100%">Schraut, Karla</style></author><author><style face="normal" font="default" size="100%">Yang, Huanqing</style></author><author><style face="normal" font="default" size="100%">Chen, Alon</style></author><author><style face="normal" font="default" size="100%">Deussing, Jan M.</style></author><author><style face="normal" font="default" size="100%">Schmidt, Mathias V.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">FKBP51 in the Oval Bed Nucleus of the Stria Terminalis Regulates Anxiety-Like Behavior</style></title><secondary-title><style face="normal" font="default" size="100%">eneuro</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021-11-01 00:00:00</style></date></pub-dates></dates><elocation-id><style  face="normal" font="default" size="100%">ENEURO.0425-21.2021</style></elocation-id><doi><style  face="normal" font="default" size="100%">10.1523/ENEURO.0425-21.2021</style></doi><volume><style face="normal" font="default" size="100%">8</style></volume><issue><style face="normal" font="default" size="100%">6</style></issue><abstract><style  face="normal" font="default" size="100%">The cochaperone FKBP51, encoded by the Fkbp5 gene, has been identified as central risk factor for anxiety-related disorders and stress system dysregulation. In the brain, the oval bed nucleus of the stria terminalis (ovBNST) has been implicated in stress-induced anxiety. However, the role of Fkbp5 in the ovBNST and its impact on anxiety-like behavior have remained unknown. Here, we show in mice that Fkbp5 in the ovBNST is reactive to acute stress and coexpressed with the stress-regulated neuropeptides Tac2 and Crh. Subsequently, results obtained from viral-mediated manipulation indicate that Fkbp5 overexpression (OE) in the ovBNST results in an anxiolytic-like tendency regarding behavior and endocrinology, whereas a Fkbp5 knock-out (KO) exposed a clear anxiogenic phenotype, indicating that native ovBNST expression and regulation is necessary for normal anxiety-related behavior. Notably, our data suggests that a stress-induced increase of Fkbp5 in the ovBNST may in fact have a protective role, leading to a transient decrease in anxiety and suppression of a future stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation. Together, our findings provide a first insight into the previously unknown relationship and effects of Fkbp5 and the ovBNST on anxiety-like behavior and HPA axis functioning.</style></abstract></record></records></xml>