RT Journal Article
SR Electronic
T1 Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0315-21.2021
DO 10.1523/ENEURO.0315-21.2021
VO 8
IS 6
A1 Candace A. Rizzi-Wise
A1 Dong V. Wang
YR 2021
UL http://www.eneuro.org/content/8/6/ENEURO.0315-21.2021.abstract
AB The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as a structure of homogeneity, exhibits such multifaceted functions. Emerging evidence suggests that different functions of the LS are mediated largely by its diverse input and output connections. It has also become clear that the LS is a heterogeneous region, where its dorsal and ventral poles play dissociable and often opposing roles. This functional heterogeneity can often be explained by distinct dorsal and ventral hippocampal inputs along the LS dorsoventral axis, as well as antagonizing connections between LS subregions. Similarly, outputs from LS subregions to respective downstream targets, such as hypothalamic, preoptic, and tegmental areas, also account for this functional heterogeneity. In this review, we provide an updated perspective on LS subregion classification, connectivity, and functions. We also identify key questions that have yet to be addressed in the field.