TY - JOUR T1 - EEG Phase-Amplitude Coupling Strength and Phase Preference: Association with Age over the First Three Years after Birth JF - eneuro JO - eNeuro DO - 10.1523/ENEURO.0264-20.2021 VL - 8 IS - 3 SP - ENEURO.0264-20.2021 AU - Michael G. Mariscal AU - April R. Levin AU - Laurel J. Gabard-Durnam AU - Wanze Xie AU - Helen Tager-Flusberg AU - Charles A. Nelson Y1 - 2021/05/01 UR - http://www.eneuro.org/content/8/3/ENEURO.0264-20.2021.abstract N2 - Phase-amplitude coupling (PAC), the coupling of the phase of slower electrophysiological oscillations with the amplitude of faster oscillations, is thought to facilitate dynamic integration of neural activity in the brain. Although the brain undergoes dramatic change and development during the first few years of life, how PAC changes through this developmental period has not been extensively studied. Here, we examined PAC through electroencephalography (EEG) data collected during an awake, eyes-open EEG collection paradigm in 98 children between the ages of three months and three years. We employed non-parametric clustering methods to identify areas of significant PAC across a range of frequency pairs and electrode locations, and examined how PAC strength and phase preference develops in these areas. We found that PAC, primarily between the α-β and γ frequencies, was positively correlated with age from early infancy to early childhood (p = 2.035 × 10−6). Additionally, we found γ over anterior electrodes coupled with the rising phase of the α-β waveform, while γ over posterior electrodes coupled with the falling phase of the α-β waveform; this regionalized phase preference became more prominent with age. This opposing trend may reflect each region’s specialization toward feedback or feedforward processing, respectively, suggesting opportunities for back translation in future studies. ER -