PT - JOURNAL ARTICLE AU - Sosa, Rodrigo AU - Mata-Luévanos, Jesús AU - Buenrostro-Jáuregui, Mario TI - The Role of the Lateral Habenula in Inhibitory Learning from Reward Omission AID - 10.1523/ENEURO.0016-21.2021 DP - 2021 May 01 TA - eneuro PG - ENEURO.0016-21.2021 VI - 8 IP - 3 4099 - http://www.eneuro.org/content/8/3/ENEURO.0016-21.2021.short 4100 - http://www.eneuro.org/content/8/3/ENEURO.0016-21.2021.full SO - eNeuro2021 May 01; 8 AB - The lateral habenula (LHb) is a phylogenetically primitive brain structure that plays a key role in learning to inhibit distinct responses to specific stimuli. This structure is activated by primary aversive stimuli, cues predicting an imminent aversive event, unexpected reward omissions, and cues associated with the omission of an expected reward. The most widely described physiological effect of LHb activation is acutely suppressing midbrain dopaminergic signaling. However, recent studies have identified multiple means by which the LHb promotes this effect as well as other mechanisms of action. These findings reveal the complex nature of LHb circuitry. The present paper reviews the role of this structure in learning from reward omission. We approach this topic from the perspective of computational models of behavioral change that account for inhibitory learning to frame key findings. Such findings are drawn from recent behavioral neuroscience studies that use novel brain imaging, stimulation, ablation, and reversible inactivation techniques. Further research and conceptual work are needed to clarify the nature of the mechanisms related to updating motivated behavior in which the LHb is involved. As yet, there is little understanding of whether such mechanisms are parallel or complementary to the well-known modulatory function of the more recently evolved prefrontal cortex.