RT Journal Article
SR Electronic
T1 Stress Controllability Modulates Basal Activity of Dopamine Neurons in the Substantia Nigra Compacta
JF eneuro
JO eNeuro
FD Society for Neuroscience
SP ENEURO.0044-21.2021
DO 10.1523/ENEURO.0044-21.2021
VO 8
IS 3
A1 Li Yao
A1 Yongfeng Li
A1 Zhijun Diao
A1 Yuanyuan Di
A1 Meilin Wu
A1 Chunling Wei
A1 Zhaoqiang Qian
A1 Zhiqiang Liu
A1 Jing Han
A1 Juan Fan
A1 Yingfang Tian
A1 Qiaohua Zheng
A1 Wei Ren
YR 2021
UL http://www.eneuro.org/content/8/3/ENEURO.0044-21.2021.abstract
AB Prolonged stress induces neural maladaptations in the mesolimbic dopamine (DA) system and produces emotional and behavioral disorders. However, the effects of stress on activity of DA neurons are diverse and complex that hinge on the type, duration, intensity, and controllability of stressors. Here, controlling the duration, intensity, and type of the stressors to be identical, we observed the effects of stressor controllability on the activity of substantia nigra pars compacta (SNc) DA neurons in mice. We found that both lack and loss of control (LOC) over shock enhance the basal activity and intrinsic excitability of SNc DA neurons via modulation of Ih current, but not via corticosterone serum level. Moreover, LOC over shock produces more significant enhancement in the basal activity of SNc DA neurons than that produced by shock per se, and therefore attenuates the response to natural reward. This attenuation can be reversed by control over shock. These results indicate that although chronic stress per se tends to enhance the basal activity of SNc DA neurons, LOC over the stressor is able to induce a larger enhancement in the basal activity of SNc DA neurons and produce more severe behavioral deficits. However, control over stress ameliorates the deleterious effects of stress, highlighting the role of stress controllability.